She played her first role in a movie when she was four years old, alongside her brother Kai Michael Müller in 4 Freunde & 4 Pfoten .
Then she was seen in other roles in each episode of the television series Polizeiruf 110 , Tatort and Rosa Roth .
Mercedes Müller played consequential 215-500 the role of Paula Bergmann in the ZDF - Telenovela Path to Happiness .
In 2009 she played the leader of the Wild Chicks , Lilli , in Die Wilden Hühner and the life of Vivian Naefe ; as well as 2014 in Sechse come the role of Lisa all over the world. In Fatih Akin's film adaptation of Wolfgang Herrndorf's Tschick , she plays Isa.
In 2020, she appeared on Oktoberfest: Beer and Blood TV series as Clara Prank.
The Berliner is also known for her appearances in the Nutella and LBS advertisements.
Müller does kickboxing at competitive sports level. Here she became German Champion in 2010, 2011, 2012 and International German Champion in 2010, 2011, 2012. In 2012 she won bronze at the World Cup.